Metabolic Syndrome in Patients with Lichen Planus- A Case Control Study

7 min

演讲者

Speaker profile

Sunil Dogra

India

Chairperson-PDS Academy Professor Dermatology, PGIMER, Chandigarh

源事件

Residents symposium

March 29, 2024Essentials series

描述

Background:- Lichen Planus (LP) is a chronic dermatosis affecting the skin and mucous membranes. Objective:- To study the association of Metabolic Syndrome in patients with Lichen Planus. Materials and Methods:- A hospital-based prospective case-control study was conducted including 75 histopathologically confirmed patients with Lichen Planus and 82 age and sex-matched controls.  Results:- Majority (30.6%) of the patients belonged to the age group 31-40 years. The mean age of patients with Lichen Planus was 46.13±14.9 years. Female predominance (69.3%) was observed in our study. Patients with classic Lichen Planus (54.6%) were predominantly observed. Metabolic Syndrome was significantly prevalent in Lichen Planus patients than in controls (32% versus 13.4%, p=0.005, OR 3.037) and was significantly associated with morphology (only oral mucosal involvement, 61.5%, p 0.027, OR 3.9), severity (severe LP, 58.6%, p<0.001, OR 7.79), and duration of the disease (> 6 months, 55.5%, p 0.001, OR 5.42). Metabolic Syndrome was predominant in females (71%) and in the fourth decade (37.5%). Systolic and Diastolic Blood Pressure values (>130/85 mm of Hg), Serum Triglycerides (>150 mg/dl), and Low-Density Lipoprotein (>130 mg/dl) were significantly elevated, and High Density Lipoprotein (<40 mg/dl) was significantly low in LP than in controls (p<0.05). Conclusion:- The study showed a significant association of Metabolic Syndrome in patients with Lichen Planus. Thus, patients with Lichen Planus need to be screened to avoid complications associated with Metabolic Syndrome i.e. Diabetes Mellitus, Cardiovascular Disease, colorectal cancer, and stroke. Keywords:- Metabolic Syndrome, Lichen Planus, Dyslipidemia, Diabetes Mellitus, Hypertension

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Mendrika Fifaliana Rakotoarisaona graduated from the University of Antananarivo, Madagascar, in 2022. She is a mentee in the GLODERM Mentorship Programme 2023-2024. Mendrika gained practical experience through internships at the Department of Dermatology University Hospital Joseph Raseta Befalatanana, Antananarivo, Madagascar, and the Department of Dermatology Nord FrancheComté Hospital, Trevenans, France. She actively participates in organisations like SOMADER, SPIM, ADF, ISAD, SFMTSI, Africaderm, ISD, and leads data collection in PASSION Dermatology. She is an author of 20 articles, sharing her expertise with the dermatological community. Her research’s interests are skin NTDs (especially leprosy, deep mycosis, scabies), teledermatology.
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Metabolic Syndrome in Patients with Lichen Planus- A Case Control Study

Chairperson-PDS Academy Professor Dermatology, PGIMER, Chandigarh
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Educational and professional training: Course Institution (Examination Board) Year Senior School Certificate Adarsha Higher Secondary School 2012 M.B.B.S. Nepalgunj Medical College, Nepalgunj (Kathmandu University) Aug 2018 In- service medical training in leprosy Anandaban Hospital, Leprosy Mission Nepal, Kathmandu 4 th Dec to 18 th Dec 2023 MD Nepal Medical Colloge, Kathmandu, Nepal May 2023 - ongoing WORK EXPERIENCE: Duration Position Details Aug 2018- Aug 2019 Intern Nepalgunj Medical College Internal Medicine, Surgery,Pediatrics, Gynecology Specialty postings (Anesthesiology, Dermatology, Orthopedics) Nov 2019- March 2021 Medical Officer Vayodha Hospital, Surgical Intensive Care Unit Jan 2020- July 2020 Medical Officer Kist Medical College, Department of Surgery Feb 2022- March 2022 Medical Officer Healthy Choice Skin Clinic, Hair transplantation unit. Jan 2022- April 2022 Medical Officer Khadki Institute of Endourology ACADEMIC ACTIVITIES: PAPERS PRESENTED: 1. E poster. ATYPICAL PRESENTATION OF HERPES GENITALIS: A CASE REPORT, Piya S, Thapa DP, Shrestha S, Rana A, Bhusal M, DERMACON 2023 2. E poster. USE OF ORAL PROPANOLOL IN THE TREATMENT OF INFANTILE HAEMANGIOMA: CASE REPORTS, Piya S, Shrestha S, Joshi S, Rana A, Thapa DP, Khanal R, Dermacon 2023 PUBLICATIONS: 1. Association between cigarette smoking and Acne Vulgaris. Nepal Medical College Journal, 25(4), 312-7. Thapa, D. P., Amatya, B., Rana, A., Ray S., Piya, S., &amp; Amrita. (2023). UNDERGOING RESEARCH: 1. Doctor’s awareness, perceptions and barriers towards medical research: a multicenter questionnaire based study. 2. Low-level light therapy in the treatment of male androgenetic alopecia: a hospital- based study. 3. Tofacitinib in treatment of alopecia areata in paediatric patients 4. Clinicoepidemiological profile of facial dermatosis in paediatric patients. 5. Quality of life in patients with alopecia: a cross-sectional questionnaire-based study 6. Adverse drug reaction reporting. 7. Clinico-epidemiological profile of the patient with photodermatosis: A hospital-based cross-sectional study NATIONAL/ INTERNATIONAL CONFERENCES&amp; WORKSHOPS / TRAININGS: 1. Syomposia on fillers for soft tissue augmentation, Association of cutaneous surgeon of Nepal 2023 2. What’s New in the Management of Acne Scars, SODVELON 2023 3. CME on moisturizers, SODVELON 2023 4. Pediatric Dermatology &amp;Dermatopathology, DI Skin hospital and referral centre 5. SODVELONCON 2023, Kathmandu, Nepal 6. PRP and Microneedling Workshop in SODVELONCON 2023. 7. Botulinum Toxin Workshop in SODVELONCON 2023
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